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Bacteriostatic water can be used for multiple draws from the same vial as long as sterile technique is followed

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The frequently observed intolerance to alcohol (the "flushing" reaction) is linked to this deficiency, which is produced by an inherited positive mutation in the corresponding gene (Yoshida et al., 1984

However, as discussed in the next section, key historical events affecting APAP use in the pediatric population have been documented that can be useful in estimating APAP use through time

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