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The promises and challenges of human brain organoids as models of neuropsychiatric disease

Nevertheless, the pooled analysis of 16 trials suggested improvements in the summary measure of patients' global functioning (assessed with the Clinical Global Impressions [CGI-I] scale) after 12 and 24 weeks of (but not after 52 weeks) of ALCAR treatment (1-3 g/day) and in cognitive performance (assessed with the Mini-Mental State Examination [MMSE] scale) after 24 weeks (but not at 12 or 52 weeks) (104)

Separation was performed using a MicroSolv Cogent Diamond Hydride column (150 mm 2.1 mm, 4.2 m, MicroSolv, Eatontown, NJ, USA), and the column was thermostated at 40 C during analysis

[DOI] [PMC free article] [PubMed] [Google Scholar] 34.Wang HH, Portincasa P, Afdhal NH, Wang DQ