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Further, the conversion of both hydroxycobalamin and cyanocobalamin to the active Adenosyl and methyl cobalamins, also involve "Flavoproteins" (Obeid etal, 2015) and hence if a person takes or is injected with, high doses of hydroxycobalamin or cyanocobalamin and has functional B2 deficiency, the inactive hydroxycobalamin and cyanocobalamin will accumulate in serum, however the symptoms of vitamin B12 deficiency will not be resolved

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Its ligands include thrombospondin-1 (TSP-1), signal-regulatory protein (SIRP), and integrins (61)

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and injections can also deplete B12

A review of vitamin B12 in dermatology