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About the first one, Giri D

doi: 10.1111/acel.12219 90 HoongCWSChuaMWJ

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The remodeling of T-tubules destroys accurate communication between L-type voltage-gated Ca 2+ channels (VGCCs), located predominantly on the T-tubule membrane, and type 2 ryanodine receptor (RyR2), a Ca 2+ -release channel located on the sarcoplasmic reticulum (108)