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PMID: 35081333 Redox Biol2022 Aug;54:102383

Another study showed that food-derived compound apigenin, a modulator of PPAR, can increase Nrf2 nucleus translocation to inhibit the expression of lipid metabolism-related genes and increase the expression of oxidative stress-related genes, resulting in amelioration of HFD-induced NAFLD [211]

These risk factors contribute to the direct causes of anaemia, such as nutrient deficiencies, blood loss, and infectious or chronic diseases, through distinct physiological mechanisms

Given our expanding knowledge of the pathogenesis of melasma, new and effective treatments are expanding our therapeutic armamentarium

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Oxidative depletion of BH 4 as a cause of eNOS uncoupling and endothelial dysfunction has been described in vivo, in the aortas of mice with deoxycorticosterone acetate-salt (DOCA-salt) hypertension [29], spontaneously hypertensive mice and rats [97, 98], apolipoprotein E (poE)-deficient mice [99], or aged mice and rats [33, 100]